## Abstract There is considerable interest in the possibility that ATP may function as a peripheral pain mediator. Most of the studies underlying this idea are electrophysiological recordings from sensory cell bodies, as nociceptive axons with diameters of 1 to 3 ΞΌm are not accessible by intracellu
P2 nucleotide receptors in osteoclasts
β Scribed by Lin N. Naemsch; Xiaobing Du; Stephen M. Sims; S. Jeffrey Dixon
- Publisher
- John Wiley and Sons
- Year
- 2001
- Tongue
- English
- Weight
- 167 KB
- Volume
- 53
- Category
- Article
- ISSN
- 0272-4391
- DOI
- 10.1002/ddr.1180
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Extracellular nucleotides like ATP bind to cell surface receptors (P2 purinergic receptors) in many tissues. P2X receptor subtypes are intrinsic ion channels that mediate depolarization and influx of Ca 2+ , whereas the P2Y receptor subtypes couple through G proteins to activation of phospholipase C
G protein-coupled P2Y nucleotide receptors have been described in cells of the immune system, including neutrophils, monocytes, macrophages, B-and T-lymphocytes, granulocytes, and myeloblasts. In the monocyte/macrophage lineage, a P2Y 2 receptor subtype activated equipotently by adenosine 5β²-triphos
## Abstract ATP is the dominant messenger for astrocyteβtoβastrocyte calciumβmediated communication. Definition of the exact ATP/P2 receptors in astrocytes and of their coupling to intracellular calcium ([Ca^2+^]~i~) has important implications for brain physiology and pathology. We show that, with