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P2-127 Reprogramming of tau exon 10 splicing by spliceosome-mediated RNA trans-splicing

✍ Scribed by Teresa Rodriguez-Martin; Mariano A. Garcia-Blanco; Gary S. Manfield; Andrew Grover; Mike Hutton; Brian H. Anderton; Jean-Marc Gallo

Book ID: 117413434
Publisher: Elsevier Science
Year: 2004
Tongue: English
Weight: 157 KB
Volume: 25
Category: Article
ISSN: 0197-4580
DOI: 10.1016/s0197-4580(04)80874-1

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## Abstract We describe the use of dynamic combinatorial chemistry (DCC) to identify ligands for the stem‐loop structure located at the exon 10‐5′‐intron junction of Tau pre‐mRNA, which is involved in the onset of several tauopathies including frontotemporal dementia with Parkinsonism linked to chr