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P1C65 - Adriamycin-induced free radical-dependent induction of the mitochondrial permeability transition

✍ Scribed by K.B. Wallace


Book ID
119539952
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
139 KB
Volume
95
Category
Article
ISSN
0378-4274

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Previously, we showed that the oxidant chemical, tert-butylhydroperoxide (t-BuOOH), induces a mitochondrial permeability transition (MPT) in intact hepatocytes, causing lethal cell injury. Here, we investigated the role of mitochondrial free Ca2+ in t-BuOOH cytotoxicity to 1-day-cultured rat hepatoc