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P17 EGFR, K-RAS and HER2 mutations as predictive factors for gefitinib sensitivity in non-small cell lung cancer (NSCLC)

โœ Scribed by A. Voutsina; A. Kalikaki; Y. Ampatziadis-Michailidis; J. Souglakos; A. Koytsopoylos; M. Trypaki; A. Pallis; S. Stathopoylos; D. Mavroudis; V. Georgoulias


Book ID
118626170
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
50 KB
Volume
5
Category
Article
ISSN
1359-6349

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## Abstract Gefitinib has shown meaningful antitumor activity with tolerable toxicity in chemotherapyโ€refractory NSCLC in previous studies. Moreover, EGFR expression failed to show a correlation with response. In an attempt to identify predictive markers of response, we have investigated the tumora