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p16MTS1/CDK4I mutations and concomitant loss of heterozygosity at 9p21-23 are frequent events in squamous cell carcinoma of the larynx

✍ Scribed by Jares, Pedro; Fernández, Pedro L; Nadal, Alfons; Cazorla, Maite; Hernández, Lluís; Pinyol, Magda; Hernández, Silvia; Traserra, Jose; Cardesa, Antonio; Campo, Elías

Book ID: 110060902
Publisher: Nature Publishing Group
Year: 1997
Tongue: English
Weight: 426 KB
Volume: 15
Category: Article
ISSN: 0950-9232
DOI: 10.1038/sj.onc.1201309

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Disregulation of p16MTS1/CDK4I protein and mRNA expression is associated with gene alterations in squamous-cell carcinoma of the larynx

✍ Pedro Jares; Alfons Nadal,; Pedro L. Fernández; Magda Pinyol; Lluis Hernández; M 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 French ⚖ 130 KB 👁 1 views

To determine the relationship between p16 MTS1/CDK4I expression, gene inactivation and 9p21 loss of heterozygosity (LOH) in the development of laryngeal carcinomas, we have examined p16 MTS1/CDK4I protein and mRNA expression in a series of 7 normal and 36 tumoral tissues, and the presence of gene al