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p16 immunohistochemistry of multiple primary melanomas as screening to identify Familial Melanoma Syndrome

โœ Scribed by Giovanni Ponti; Gabriele Luppi; Lorena Losi; Anna Maria Cesinaro; Giuliana Sartori; Antonio Maiorana; Giovanni Pellacani; Caterina Longo; Elisa Boni; Patrizia Pepe; Alberto Giannetti; Stefania Seidenari; Maria Teresa Landi


Book ID
110879159
Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
173 KB
Volume
51
Category
Article
ISSN
0011-9059

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Mutation analysis of two genes involved in melanoma susceptibility (CDKN2A/p16 INK4a and CDK4) was undertaken in 131 probands with a family history of melanoma. Screening of all three exons of CDKN2A and exon 2 of CDK4 by single-strand conformation polymorphism (SSCP) analysis and/or direct sequenci