Alteration of p16 and p15 genes in commo
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Masami Fujita; Takayuki Enomoto; Tomoko Haba; Ryuichi Nakashima; Makoto Sasaki;
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Article
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1997
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John Wiley and Sons
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French
β 244 KB
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We have examined the roles of 2 putative tumor-suppressor genes, the p16 and p15 inhibitor-of-cyclin-dependentkinase genes, in the most commonly occurring epithelial tumors of the human ovary. Expression of p16 mRNA, examined by RT-PCR, was significantly reduced in 15 of the 48 tumors. Aberrant expr