P149 Evaluation of family histories and analysis of BRCA1 founder mutations in a population-based series of breast and ovarian cancer cases in Latvia
β Scribed by G. Plakhins; A. Irmejs; A. Gardovskis; S. Subatniece; S. Rozite; U. Teibe; G. Trofimovics; E. Miklasevics; J. Gardovskis
- Book ID
- 114316489
- Publisher
- Elsevier Science
- Year
- 2011
- Tongue
- English
- Weight
- 38 KB
- Volume
- 20
- Category
- Article
- ISSN
- 0960-9776
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## Abstract Germβline mutations within __BRCA1__ are responsible for different proportions of inherited susceptibility to breast/ovarian cancer, and the spectrum of mutations within this gene is often unique to certain populations. At this time, there have been no reports regarding the role of __BR
Previous mutational analysis for BRCA gene mutations in sporadic ovarian cancer occurring in Chinese patients in Hong Kong identified six germline BRCA1 mutations and one germline BRCA2 mutation, six of which were novel (Khoo et al., 2000). Knowledge of BRCA gene mutations in the Chinese population