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P137 INDUCTION OF INCREASED CAMP LEVELS IN ARTICULAR CHONDROCYTES BLOCKS MATRIX METALLOPROTEINASE AND AGGRECANASE MEDIATED CARTILAGE DEGRADATION

✍ Scribed by M.A. Karsdal; E. Sumer; S.H. Madsen; C. Christiansen; P. Qvist; B.C. Sondergaard

Book ID
114349484
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
40 KB
Volume
14
Category
Article
ISSN
1063-4584

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Induction of increased cAMP levels in articular chondrocytes blocks matrix metalloproteinase–mediated cartilage degradation, but not aggrecanase-mediated cartilage degradation
✍ Morten Asser Karsdal; Eren Ufuk Sumer; Helle Wulf; Suzi H. Madsen; Claus Christi 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 223 KB 👁 2 views

## Abstract ## Objective Calcitonin has been suggested to have chondroprotective effects. One signaling pathway of calcitonin is via the second messenger cAMP. We undertook this study to investigate whether increased cAMP levels in chondrocytes would be chondroprotective. ## Methods Cartilage de