p130Cas, an Assembling Molecule of Actin Filaments, Promotes Cell Movement, Cell Migration, and Cell Spreading in Fibroblasts

Focal adhesion targeting of v-Crk is ess

Focal adhesion targeting of v-Crk is essential for FAK phosphorylation and cell migration in mouse embryo fibroblasts deficient src family kinases or p130CAS

✍ Myeong Gu Yeo; Bong Hwan Sung; Hye Jin Oh; Zee Yong Park; Eugene E. Marcantonio; 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 540 KB

## Abstract We examined the consequences of v‐Crk expression in mouse embryo fibroblasts deficient Src family kinases or p130CAS. We found that Src kinases are essential for p130CAS/v‐Crk signaling leading to FAK phosphorylation and cell migration in which Src is likely to mediate the focal adhesio