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P13 Absorption enhancement of hydrophilic compounds by racemic verapamil after rectal administration in rats

โœ Scribed by A.B.J. Noach; M.C.M. Blom-Roosemalen; A.G. de Boer; D.D. Breimer


Book ID
113275730
Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
166 KB
Volume
29
Category
Article
ISSN
0168-3659

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The oral absorption of iothalamate and the effect of amino acids on its absorption were studied in 6 dogs and 6 rats using a simple HPLC assay. The results showed that iothalamate was absorbed in dogs. averaging 9.9, 8.5. and 10.0 per cent following the administration of 40 and 100mg kg-' of iothala