## Abstract Gait disturbances and akinesia are disabling symptoms in advanced Parkinson's disease (PD). The pedunculopontine nucleus (PPN) is involved in locomotion, control of posture, and behavioral states [i.e. wakefulness, rapid eye movement (REM) sleep]. Some reports have suggested that modula
P1.105 rCBF changes associated with pathological gambling in Parkinson's disease: a H215O PET study
โ Scribed by T. Van Eimeren; G. Pellecchia; J. Miyasaki; B. Ballanger; T. Steeves; S. Houle; A. Lang; A. Strafella
- Book ID
- 117753430
- Publisher
- Elsevier Science
- Year
- 2009
- Tongue
- English
- Weight
- 57 KB
- Volume
- 15
- Category
- Article
- ISSN
- 1353-8020
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Background: Pathological gambling may occur in Parkinson's disease (PD) as a complication of dopaminergic therapy. Neuroimaging studies have suggested an abnormal dopamine transmission within the reward system, but the changes in the neural network characterizing PD patients with pathological gambli
## Abstract Patients with advanced Parkinson's disease (PD) develop disabling axial symptoms, including gait disturbances, freezing and postural instability poorly responsive to levodopa replacement therapy. The pedunculopontine nucleus (PPN) is involved in locomotion, control of posture, and behav