P106 Proliferation and collagen type I expression of osteoarthritic osteoblasts are induced by CXCL12 (SDF-1) and CXCL13 (BCA-1) chemokines

CXCL12 (SDF-1) and CXCL13 (BCA-1) chemok

CXCL12 (SDF-1) and CXCL13 (BCA-1) chemokines significantly induce proliferation and collagen type I expression in osteoblasts from osteoarthritis patients

✍ Gina Lisignoli; Stefania Toneguzzi; Anna Piacentini; Sandra Cristino; Francesco 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 390 KB

## Abstract To evaluate the role of CXC chemokines CXCL8 (IL8), CXCL10 (IP‐10), CXCL12 (SDF‐1), and CXCL13 (BCA‐1) in bone remodeling, we analyzed their effects on osteoblasts (OBs) obtained from subchondral trabecular bone tissue of osteoarthritis (OA) and post‐traumatic (PT) patients. The express