The demethylation of amitriptyline: A cr
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J. E. Burch
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Article
📅
1983
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Springer
🌐
English
⚖ 506 KB
Five elderly depressed patients were treated with amitriptyline (AT) and nortriptyline (NT) in turn, in a crossover design. Steady-state plasma drug levels were compared with those calculated for eight healthy subjects of previous single-dose studies. Plasma clearances were on average about 2.5 time