P101 Coincidental occurrence of RBC and HLA class I antibodies in renal transplant patients
✍ Scribed by L. Kozma; M. Lukovics; I. Bohaty
- Publisher
- Elsevier Science
- Year
- 2007
- Tongue
- English
- Weight
- 46 KB
- Volume
- 21
- Category
- Article
- ISSN
- 0268-960X
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✦ Synopsis
Results: Platelet antibodies were detected in 6 of the 15 maternal serums. The specificity of the antibodies were anti-HPA-1a (n = 3), HPA-5b (n = 3), anti-HLA (n = 3), and anti-HLA+panreactive HPA (n = 3). The cross-matches with paternal platelets were positive in these cases. Antibodies were not detected in 9 of 15 maternal blood samples, and paternal crossmatches were negative as well. Four new maternal serums of the initial negative cases were retested 2 4 weeks later and no antibodies were detected. Conclusion: Identification of platelet antibodies in the maternal blood sample is the main support in the differential diagnosis and management of NAIT. We could detect maternal platelet antibodies against paternal platelets in 40% of suspected NAIT cases, helping this way the better management of newborns and subsequent pregnancies.