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P.1.002 Pharmacological characterisation of positive allosteric modulators acting on the metabotropic glutamate receptor 2

✍ Scribed by Bennett, K.A.; Weaver, A.; Marshall, F.; Langmead, C.J.


Book ID
122101207
Publisher
Elsevier Science
Year
2013
Tongue
English
Weight
64 KB
Volume
23
Category
Article
ISSN
0924-977X

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## Abstract 2‐(3,5‐Dichlorophenylcarbamoyl)cyclohexanecarboxylic acid (**1**) is a potent and selective positive allosteric modulator of metabotropic glutamate receptor subtypeβ€…4 (mGluR4). The activity of **1** was reported to reside in the __cis__ diastereomer with equal potency between its enanti