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P1-335: A powerful association analysis of 496 SNPs in 80 positional candidate genes in a linked region on chromosome 10 for association with late onset Alzheimer’s disease

✍ Scribed by Richard Abraham; Angharad R. Morgan; Luke Jehu; Dragana Turic; Gillian Hamilton; Paul Hollingworth; Pamela Moore; Kimberley Dowzell; Peter Holmans; Valentina Moskvina; Natalie Cope; John Powell; Simon Lovestone; Carol Brayne; David C. Rubinsztein; Michael O’Donovan; Michael J. Owen; Julie Williams; Julie Williams

Book ID: 118462784
Publisher: Elsevier Science
Year: 2006
Tongue: English
Weight: 57 KB
Volume: 2
Category: Article
ISSN: 1552-5260
DOI: 10.1016/j.jalz.2006.05.713

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## Abstract Late‐onset Alzheimer's disease (LOAD) is a genetically complex neurodegenerative disorder. Currently, only the ε4 allele of the Apolipoprotein E gene has been identified unequivocally as a genetic susceptibility factor for LOAD. Others remain to be found. In 2002 we observed genome‐wide