P1-213 ADAM10, ADAM17 and BACE1 downregulation in HEK293 cells: effects on APP metabolism

Interleukin-1α stimulates non-amyloidoge

Interleukin-1α stimulates non-amyloidogenic pathway by α-secretase (ADAM-10 and ADAM-17) cleavage of APP in human astrocytic cells involving p38 MAP kinase

✍ Sanghamitra Bandyopadhyay; Dean M. Hartley; Catherine M. Cahill; Debomay K. Lahi 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 542 KB

## Abstract Interleukin‐1α (IL‐1α) stimulates a disintegrin and metalloproteinase, ADAM‐17 synthesis, consistent with activation of the soluble fragment of Amyloid Precursor Protein, APP, (sAPPα) in human primary astrocytes. To characterize the mechanism by which IL‐1α promotes the non‐amyloidogeni