P.088 Sensitivity of hepatitis B surface antigen assays to detect HBsAg mutant forms
✍ Scribed by S. Laperche; T. Ly; A. Servant-Delmas; S. Bagot; S. Gonzalo; M. Férey; A. Ebel; E. Dussaix; A. Roque-Afonso
- Book ID
- 117770311
- Publisher
- Elsevier Science
- Year
- 2006
- Tongue
- English
- Weight
- 132 KB
- Volume
- 36
- Category
- Article
- ISSN
- 1386-6532
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## Abstract The sensitivity of immunoassays for hepatitis B virus (HBV) surface antigen (HBsAg) detection may be hampered by the presence of mutants involving the major antigenic determinant of the protein. The performance of the VITROS® HBsAg Assay has been shown to be affected by mutations compri
A cherniluminescent assay for hepatitis-B surface antigen is described which used an isoluminol derivative as the label. The assay is precise intra-assay CV, 1.96-2.45%; inter-assay CV, 5 2 6 8 . 1 1 % and has a lower detection limit for hepatitis-B surface antigen of 1.3 UA.