P057 Chronic relapsing thrombotic thrombocytopenic purpura in a 32 years old diabetic male with ADAMTS 13 protease deficiency treated succesfully with plasma infusions and steroids
✍ Scribed by A.T. Lopez-Enriquez
- Publisher
- Elsevier Science
- Year
- 2007
- Tongue
- English
- Weight
- 48 KB
- Volume
- 21
- Category
- Article
- ISSN
- 0268-960X
No coin nor oath required. For personal study only.
✦ Synopsis
the elevated TAT complex and D-dimer levels; reflecting activation of coagulation cascade with subsequent fibrinolysis and hence the occurrence of disseminated intravascular coagulation (DIC).
Conclusion:
The association of activated platelets, injured ECs and DIC may suggest the possible implication of enhanced platelet-EC interaction in the causation of thrombocytopenia in CLD. The prompt control of endotoxaemia known to occur in the late stages of CLD may be the key for rescuing the patients from the deleterious effects of platelet activation, EC injury and caogulopathy.
P057 Chronic relapsing thrombotic thrombocytopenic purpura in a 32 years old diabetic male with ADAMTS 13 protease deficiency treated succesfully with plasma infusions and steroids