P.050 Appearance of core antigen negative hepatocytes in woodchucks chronically infected with woodchuck hepatitis virus
β Scribed by C. Xu; T. Yamamoto; T. Zhou; C. Aldrich; J.M. Cullen; A.R. Jilbert; W.S. Mason
- Book ID
- 117770273
- Publisher
- Elsevier Science
- Year
- 2006
- Tongue
- English
- Weight
- 148 KB
- Volume
- 36
- Category
- Article
- ISSN
- 1386-6532
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T-cell responses to hepatitis B virus nucleocapsid antigens (HBcAg and HBeAg) play an important role in disease outcome in those infected with hepatitis B virus (HBV). The woodchuck is naturally infected in the wild with woodchuck hepatitis virus (WHV), which shows a high degree of genetic homology
## Abstract Four woodchucks chronically infected with hepatitis delta virus (HDV) were treated with cyclosporinβA (CyA) for 11 weeks. All animals had detectable HDAg in the liver and two of them were also positive for HDAg and HDVβRNA in serum. Reappearance of HDV in serum was noted in one of the t