P039 Cooperativity between bone marrow cells and culture-expanded mesenchymal stem cells during reversal of type-1 diabetes
✍ Scribed by V.S. Urbán; J. Kiss; J. Kovács; V. Vas; É. Monostori; F. Uher
- Book ID
- 104323104
- Publisher
- Elsevier Science
- Year
- 2007
- Tongue
- English
- Weight
- 51 KB
- Volume
- 21
- Category
- Article
- ISSN
- 0268-960X
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✦ Synopsis
to investigate the Hp polymorphism distribution in Hungarian patients with chronic lymphocytic leukemia (CLL). Methods: 120 Hungarian CLL patients were investigated (m/f ratio: 65/55, age 62.8±10.7 ys, duration 47,5±37,7 months, Rai clinical stage 0/I-II/III-IV 22.5%-62.5%-15%) and 384 healthy subjects served as controls. Hp phenotypes were determined by sodium dodecyl sulphate-polyacrylamide gel electrophoresis of sera followed by immunoblotting. Prognostic data (lymphocyte doubling time, serum LDH level, ZAP-70, CD38, FISH), immunoglobulin levels and infectious episodes were determined. Results: The phenotype distribution of Hp polymorphism showed no differences between patients and controls (Hp 1 1, 2 1 and 2 2 type was 10.4% vs. 11.5%, 51% vs. 46.1% and 38.6% vs. 42.4%, respectively). Hp phenotypes were associated to prognosis in patients with CLL but neither to age at onset nor to increased risk for pneumonia. Conclusions: Our findings suggest a disease-modifying role for Hp polymorphism in patients with CLL.