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p -Nitromandelic Acid as a Highly Acid-Stable Safety-Catch Linker for Solid-Phase Synthesis of Peptide and Depsipeptide Acids

✍ Scribed by Isidro-Llobet, Albert; Alvarez, Mercedes; Burger, Klaus; Spengler, Jan; Albericio, Fernando


Book ID
126841656
Publisher
American Chemical Society
Year
2007
Tongue
English
Weight
144 KB
Volume
9
Category
Article
ISSN
1523-7060

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πŸ“œ SIMILAR VOLUMES


4-(3-Hydroxy-4-methylpentyl)phenylacetic
✍ Katri Rosenthal; Mikael Erlandsson; Anders UndΓ©n πŸ“‚ Article πŸ“… 1999 πŸ› Elsevier Science 🌐 French βš– 200 KB

The anchoring the first amino acid in Boc chemistry to a 4-(3-hydroxy-4methylpentyl)phenylacetic acid linker is described and compared to the conventional Pam resin. The peptidyl-4-(4-methyl-3-pentoxy)phenylacetamide linkage is slightly more stable to TFA than the Pam linker but in contrast to the P