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P IX.10 - P IX.10 Induction and rejoining of DNA single — and double — strand breaks in normal and DNA ligase deficient cells

✍ Scribed by Silvano Nocentini

Book ID
114071727
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
134 KB
Volume
379
Category
Article
ISSN
0027-5107

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## Abstract Wortmannin (WM) is a potent inhibitor of the catalytic sub‐unit of DNA‐PK, which is involved in one pathway of DNA double‐strand break (DSB) rejoining, and of ATM, which functions upstream in the p53 signaling pathway. WM is known to be an efficient radiosensitizer in a variety of mamma