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P-glycoprotein plays a role in the oral absorption of BMS-387032, a potent cyclin-dependent kinase 2 inhibitor, in rats

✍ Scribed by Amrita V. Kamath; Saeho Chong; Ming Chang; Punit H. Marathe


Book ID
105992027
Publisher
Springer
Year
2004
Tongue
English
Weight
262 KB
Volume
55
Category
Article
ISSN
0344-5704

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BMS-262084 is a potent and selective b-lactam tryptase inhibitor with therapeutic potential for treating asthma. The oral bioavailability of BMS-262084 was low in rats (4% at a dose of 0.5 mg/kg) due to poor absorption. BMS-262084 was excreted mainly unchanged in the urine, suggesting minimal metabo