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P-glycoprotein (P-gp) function in T cells: implications for organ transplantation

✍ Scribed by Vera S. Donnenberg; Gilbert J. Burckart; Albert D. Donnenberg


Book ID
114412869
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
448 KB
Volume
4
Category
Article
ISSN
1529-1049

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Rat hepatoma cells lacking mitochondrial DNA (Β°cells) were used as a model system to examine the possible roles of mitochondrial DNA as a target for the DNA-acting anticancer drug Adriamycin (doxorubicin). The Β°c ells were 45-fold less sensitive to Adriamycin than the parental Ο© cells containing mit