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P-glycoprotein mediated efflux in Caco-2 cell monolayers: The influence of herbals on digoxin transport

✍ Scribed by Enoche F. Oga; Shuichi Sekine; Yoshihisa Shitara; Toshiharu Horie

Book ID
119295548
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
353 KB
Volume
144
Category
Article
ISSN
0378-8741

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P-glycoprotein–mediated transport of ber
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✍ Han-Joo Maeng; Ho-Jung Yoo; In-Wha Kim; Im-Sook Song; Suk-Jae Chung; Chang-Koo S πŸ“‚ Article πŸ“… 2002 πŸ› John Wiley and Sons 🌐 English βš– 116 KB

The objective of this study was to investigate the mechanisms by which berberine is transported in the secretory and absorptive directions across Caco-2 cell monolayers. The basolateral-to-apical (B-A) flux was 30-fold greater than the apical-to-basolateral flux and temperature dependent (i.e., dras