P-Glycoprotein Is Positively Correlated with p53 Protein Accumulation in Human Colorectal Cancers
β Scribed by Oka, Mikio ;Kounoura, Kiyoshi ;Narasaki, Fumihiko ;Sakamoto, Akira ;Fukuda, Minoru ;Matsuo, Isao ;Ikeda, Koki ;Tsurutani, Junji ;Ikuno, Nobuhiro ;Omagari, Katsuhisa ;Mizuta, Yohei ;Soda, Hiroshi ;Gudas, Jean M. ;Kohno, Shigeru
- Book ID
- 108581472
- Publisher
- Wiley (Blackwell Publishing)
- Year
- 1997
- Tongue
- English
- Weight
- 590 KB
- Volume
- 88
- Category
- Article
- ISSN
- 0910-5050
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
P-glycoprotein (Pgp) encoded by the MDR1 gene, a predictor of chemoresistance, may also serve as a prognosticator of clinical outcome in cancer patients. The mutant tumour-suppressor p53 protein has been shown to activate the MDR1 promoter, whereas the wild-type p53 represses this activity in cultur
Previous studies have shown that nuclear p53 over-expression is an indicator of p53 mutations whereas cytoplasmic p53 accumulation is related to wild-type p53 in several kinds of tumors. Cytoplasmic p53 accumulation has been demonstrated to be an independent prognostic factor in colorectal adenocarc
Only half of colorectal-cancer patients elicit serum antibodies in response to intratumoral p53-gene mutations. Our study was designed to compare cellular events (p53-protein accumulation and gene mutations) with the presence of circulating anti-p53 antibodies (p53-Ab). Thirty-five colorectalcancer