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P-glycoprotein drug transporter MDR1 gene polymorphism in renal transplant patients with and without gingival overgrowth

✍ Scribed by M. Drozdzik; K. Mysliwiec; M. Lewinska-Chelstowska; J. Banach; A. Drozdzik; J. Grabarek


Book ID
109359453
Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
132 KB
Volume
31
Category
Article
ISSN
0303-6979

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Drug resistance, both primary and acquired, is a major obstacle to advances in cancer chemotherapy. In vitro, multidrug resistance can be mediated by P-glycoprotein (PGY1), a cell surface phosphoglycoprotein that acts to efflux natural products from cells. PGY1 is encoded by the MDR1 gene located at