✦ LIBER ✦

p-fluoro-hexahydro-sila-difenidol: The first M2β-selective muscarinic antagonist

✍ Scribed by Günter Lambrecht; Roland Feifel; Bernhard Forth; Carsten Strohmann; Reinhold Tacke; Ernst Mutschler

Book ID: 115882045
Publisher: Elsevier Science
Year: 1988
Tongue: English
Weight: 149 KB
Volume: 152
Category: Article
ISSN: 0014-2999
DOI: 10.1016/0014-2999(88)90856-4

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

ChemInform Abstract: Unsaturated Derivat

ChemInform Abstract: Unsaturated Derivatives of the Muscarinic Antagonists Hexahydro-sila- difenidol (HHSiD) and p-Fluoro-hexahydro-sila-difenidol (p-F-HHSiD) with an (E)-Si-CH=CH-CH2-N Moiety: Syntheses and Binding Affinities at Muscarinic Receptor Subtypes.

✍ R. TACKE; B. FORTH; M. WAELBROECK; J. GROSS; E. MUTSCHLER; G. LAMBRECHT 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 34 KB

Unsaturated derivatives of the muscarini

Unsaturated derivatives of the muscarinic antagonists hexahydro-sila-difenidol (HHSiD) and p-fluoro-hexahydro-sila-difenidol (p-F-HHSiD) with an (E)-SiCHCHCH2rmN moiety: Syntheses and binding affinities at muscarinic receptor subtypes

✍ Reinhold Tacke; Bernhard Forth; Magali Waelbroeck; Jan Gross; Ernst Mutschler; G 📂 Article 📅 1995 🏛 Elsevier Science 🌐 English ⚖ 622 KB

2-Methylimidazol-1-yl-Substituted Analog

2-Methylimidazol-1-yl-Substituted Analogs of Hexahydro-difenidol (HHD) and Hexahydro-sila-difenidol (HHSiD) as M 3 Receptor-Preferring Muscarinic Antagonists: A Study on C/Si Bioisosterism

✍ Tacke, Reinhold; Handmann, Vera I.; Kreutzmann, Kai; Keim, Christine; Mutschler, 📂 Article 📅 2002 🏛 American Chemical Society 🌐 English ⚖ 108 KB

Enantiomers of the muscarinic antagonist

Enantiomers of the muscarinic antagonist 1-cyclohexyl-1-(4-fluorophenyl)-4-piperidino-1-butanol (p-fluoro-hexahydro-difenidol): Synthesis, absolute configuration, and enantiomeric purity

✍ Strohmann, Carsten ;Bauerecker, Sigurd ;Cammenga, Heiko K. ;Jones, Peter G. ;Mut 📂 Article 📅 1991 🏛 John Wiley and Sons 🌐 English ⚖ 533 KB

## Abstract The enantiomers of the antimuscarinic agent 1‐cyclohexyl‐1‐(4‐fluorophenyl)‐4‐piperidino‐1‐butanol [(__R__)‐ and (__S__)‐__p__‐fluorohexahydro‐difenidol] [(__R__)‐ and (__S__)‐2a] and their methiodides (__R__)‐3 and (__S__)‐3 were prepared with high enantiomeric purity. (__R__)‐2a and (

The effect of absolute configuration on

The effect of absolute configuration on activity, subtype selectivity (M3/M2) of 3α-acyloxy-6β-acetoxyltropane derivatives as muscarinic M3 receptor antagonists

✍ Wang, Zhi-Peng; Liu, Hui-Zhong; Zhu, Liang; Hu, You-Min; Cui, Yong-Yao; Niu, Yin 📂 Article 📅 2013 🏛 Elsevier Science 🌐 English ⚖ 490 KB