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p-Chlorophenylalanine-induced alterations in the behavioral effects of 5-hydroxytryptophan

โœ Scribed by W. O. Boggan; D. X. Freedman; J. B. Appel

Publisher
Springer
Year
1973
Tongue
English
Weight
398 KB
Volume
33
Category
Article
ISSN
0033-3158

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โœฆ Synopsis

l~'etreatment of rats with p-chlorophenylalanine methyl ester (PCPA-ME) causes a normally non-effective dose of 5-hydroxytryptophan (5-HTP) to disrupt bar-pressing at times when serotonin (5-HT) concentration is depleted. There does not appear to be any correlation between the initial, behaviorallydistruptive effects of PCPA-ME and the action of this compound on 5-HT biosynthesis.

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