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P-629 A phase I study of erlotinib (TarcevaTM) monotherapy in Japanese patients with non-small cell lung cancer and other solid tumors

โœ Scribed by Atsushi, Horiike; Yamada, Yasuhide; Yamamoto, Noboru; Shimoyama, Tatsu; Murakami, Haruyasu; Fujisake, Yasuhito; Takayama, Kyoko; Sakamoto, Terumi; Tamura, Tomohide


Book ID
118572324
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
193 KB
Volume
41
Category
Article
ISSN
0169-5002

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โœ Gandhi, L.; Camidge, D. R.; Ribeiro de Oliveira, M.; Bonomi, P.; Gandara, D.; Kh ๐Ÿ“‚ Article ๐Ÿ“… 2011 ๐Ÿ› American Society of Clinical Oncology ๐ŸŒ English โš– 299 KB

## Purpose Resistance to chemotherapy-induced apoptosis represents a major obstacle to cancer control. Overexpression of Bcl-2 is seen in multiple tumor types and targeting Bcl-2 may provide therapeutic benefit. A phase I study of navitoclax, a novel inhibitor of Bcl-2 family proteins, was conduct