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P-50 ESTROGEN RECEPTOR AND IGF-1R IN BREAST CANCER CELLS: WHAT IS THE RELATIONSHIP?

✍ Scribed by Ada Girnita; Leonard Girnita; Magnus Axelson; Olle Larsson

Book ID
117734529
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
46 KB
Volume
16
Category
Article
ISSN
1096-6374

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Estrogen regulated expression of the p21
Estrogen regulated expression of the p21Waf1/Cip1 gene in estrogen receptor positive human breast cancer cells
✍ Soma Mandal; James R. Davie πŸ“‚ Article πŸ“… 2010 πŸ› John Wiley and Sons 🌐 English βš– 183 KB

## Abstract The cyclin‐dependent kinase inhibitor protein p21^Waf1/Cip1^ is a potent tumor suppressor. Here, we demonstrate that estradiol regulates the p21^Waf1/Cip1^ gene. Estradiol induces p21^Waf1/Cip1^ mRNA expression within 30–60 min independent of new protein synthesis in the estrogen recept