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P-2-8 - The effects of ziprasidone on steady-state lithium levels and renal clearance of lithium

✍ Scribed by K.D. Wilner; R.J. Anziano; T.G. Tensfeldt; S.M. Pelletier; G. Apseloff; N. Gerber


Book ID
119177171
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
139 KB
Volume
6
Category
Article
ISSN
0924-977X

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A group of 15 rats received two intravenous bolus doses of antipyrine (15 mg/kg) separated by a 57 hour infusion (with bolus dose) of phenobarbital. Phenobarbital bolus doses and infusion rates were based on a preliminary pharmacokinetic study (7 rats) and were varied to achieve a broad range of ste