p-[18F]-MPPF PET imaging of 5-HT1A receptor binding in marmoset brain
β Scribed by Alexander K. Converse; Y. Aubert; D. Murali; J.P. Weichert; O.T. DeJesus; R.J. Nickles; D.H. Abbott
- Book ID
- 118491122
- Publisher
- Elsevier Science
- Year
- 2008
- Tongue
- English
- Weight
- 79 KB
- Volume
- 41
- Category
- Article
- ISSN
- 1053-8119
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π SIMILAR VOLUMES
The purpose of this study was to develop a radiopharmaceutical that could be used to selectively image 5-HT 1A receptors with positron emission tomography (PET). No-carrier-added 4-(28-methoxyphenyl)-1-[28-(N-29-pyridinyl)-p-[ 18 F]fluorobenzamido]ethylpiperazine ( p-[ 18 F]-MPPF, 2) was synthesized
The in vivo and ex vivo distributions and the pharmacological profile of the fluorinated phenylpiperazine derivative p-[ 18 F]MPPF (4-(2Π-methoxyphenyl)-1-[2Π-(N-2Π-pyridinyl)-p-fluorobenzamido]-ethylpiperazine) were evaluated in the cat brain as a potential selective antagonist for 5-HT 1A receptor