The present work was aimed at assessing the GTP-binding (Galphas subunit) protein expression in lithium-treated bipolar patients (BP). Mononuclear leukocyte Galphas protein and mRNA were measured both in patients and in a comparison group. The patient group consisted of 15 lithium-treated patients w
✦ LIBER ✦
P-18-16 - Increased levels of Gαs in platelets of euthymic bipolar affective disorder patients
✍ Scribed by P. Mitchell; H.K. Manji; G. Chen; L. Jolkovsky; E. Smith-Jackson; K. Denicoff; M. Schmidt; W.Z. Potter
- Book ID
- 119177860
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- English
- Weight
- 150 KB
- Volume
- 6
- Category
- Article
- ISSN
- 0924-977X
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## Abstract Reports of elevated Gs α subunit (α~s~) immunolabeling and cAMP‐mediated hyper‐functionality in autopsied cerebral cortical brain regions from bipolar affective disorder (BD) patients suggest signal transduction abnormalities occur in this disorder. Because covalent modification of α~s~