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P-167 p53 status and its in vitro relation to radiosensitivity in lung cancer

✍ Scribed by Bergqvist, Michael; Brattstrom, Daniel; Hesselius, Patrik; Gullbo, Joachim; Wagenius, Gunnar; Brodin, Ola


Book ID
118571868
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
188 KB
Volume
41
Category
Article
ISSN
0169-5002

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Cell cycle deregulation can occur at different levels in cancer. In human breast cancer it includes overexpression of cyclins D1 and E, down-regulation of cyclin-dependent kinase inhibitors and inactivation of the retinoblastoma and p53 tumor suppressor proteins. Telomerase activity is strongly asso