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P-128 Regulation of RAD51 levels in response to etoposide (VP16) induced DNA strand breaks in small cell lung cancer cells

✍ Scribed by Hansen, Lasse Tengbjerg; Helleday, Thomas; Sørensen, Claus Storgaard; Spang-Thomsen, Mogens

Book ID
118571829
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
188 KB
Volume
41
Category
Article
ISSN
0169-5002

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The role of RAD51 in etoposide (VP16) re
The role of RAD51 in etoposide (VP16) resistance in small cell lung cancer
✍ Lasse Tengbjerg Hansen; Cecilia Lundin; Mogens Spang-Thomsen; Lone Nørgård Peter 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 French ⚖ 465 KB

## Abstract Etoposide (VP16) is a potent inducer of DNA double‐strand breaks (DSBs) and is efficiently used in small cell lung cancer (SCLC) therapy. However, acquired VP16 resistance remains an important barrier to effective treatment. To understand the underlying mechanisms for VP16 resistance in