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Oxytocin with N5,N5-dimethylglutamine and N4,N4-dimethylasparagine in the 4 and 5 positions: synthesis, pharmacological properties and mass spectral analysis

โœ Scribed by Dimitrios Theodoropoulos; Paul Cordopatis; Demetrios Dalietos; Arthur Furst; Terry D Lee


Book ID
103628988
Publisher
Elsevier Science
Year
1987
Tongue
French
Weight
277 KB
Volume
22
Category
Article
ISSN
0223-5234

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โœ Ramachandran P Subrayan; Paul G Rasmussen ๐Ÿ“‚ Article ๐Ÿ“… 1999 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 355 KB

Cyanation of bis(4,5-dicyano-l-methyl-2-imidazolyl)arnine(1) using cyanogen chloride gave N,N-bis(4,5-dicyano-l-methyl-2-imidazolyl)cyanamide(3) as a light yellow solid. Compound 3 is themmlly labile and upon heating the N-CN bond is cleaved and the reactive amine intermediate readily reacts with th