Oxygenation-sensitive CMR for assessing vasodilator-induced changes of myocardial oxygenation

✍ Scribed by Matthias Vöhringer; Jacqueline A Flewitt; Jordin D Green; Rohan Dharmakumar; Jiun Wang; John V Tyberg; Matthias G Friedrich

• Book ID: 104498053
• Publisher: BioMed Central
• Year: 2010
• Tongue: English
• Weight: 704 KB
• Volume: 12
• Category: Article
• ISSN: 1097-6647
• DOI: 10.1186/1532-429x-12-20

✦ Synopsis

Abstract

Background

As myocardial oxygenation may serve as a marker for ischemia and microvascular dysfunction, it could be clinically useful to have a non-invasive measure of changes in myocardial oxygenation. However, the impact of induced blood flow changes on oxygenation is not well understood. We used oxygenation-sensitive CMR to assess the relations between myocardial oxygenation and coronary sinus blood oxygen saturation (SvO~2~) and coronary blood flow in a dog model in which hyperemia was induced by intracoronary administration of vasodilators.

Results

During administration of acetylcholine and adenosine, CMR signal intensity correlated linearly with simultaneously measured SvO~2~ (r
^2^ = 0.74, P < 0.001). Both SvO~2~ and CMR signal intensity were exponentially related to coronary blood flow, with SvO2 approaching 87%.

Conclusions

Myocardial oxygenation as assessed with oxygenation-sensitive CMR imaging is linearly related to SvO~2~ and is exponentially related to vasodilator-induced increases of blood flow. Oxygenation-sensitive CMR may be useful to assess ischemia and microvascular function in patients. Its clinical utility should be evaluated.