Oxygenation in tumors by modified hemogl
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Nozue, Mutsumi; Lee, Intae; Manning, James M.; Manning, Lois R.; Jain, Rakesh K.
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Article
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1996
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John Wiley and Sons
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English
β 515 KB
The effect of systemic injection of modified hemoglobin (Hb) prepared from bovine, human, or mouse Hb on tumor oxygenation was investigated. Hb was modified by (1) diisothiocyanatobenzenesulfonate (DIBS) to yield cross-linking within a tetramer; (2) glycolaldehyde (Glyal) to yield crosslinking betwe