Oxygenation of hypoxic region in solid tumor by administration of human serum albumin incorporating synthetic hemes
✍ Scribed by Kobayashi, Koichi ;Komatsu, Teruyuki ;Iwamaru, Arifumi ;Matsukawa, Yasuko ;Horinouchi, Hirohisa ;Watanabe, Masazumi ;Tsuchida, Eishun
- Book ID
- 102291469
- Publisher
- John Wiley and Sons
- Year
- 2002
- Tongue
- English
- Weight
- 71 KB
- Volume
- 64A
- Category
- Article
- ISSN
- 0021-9304
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✦ Synopsis
Abstract
Recombinant human serum albumin incorporating synthetic heme (rHSA‐FeP) was tested for its ability to increase O~2~ tension in the hypoxia of the solid tumor rat model. By the direct administration of the rHSA‐FeP solution (10 mL/kg) via the aorta descendens to the ascites hepatoma LY80 tumor on the right femur, the O~2~ tension of the hypoxic region immediately increased to 3.45 ± 1.43 Torr, which corresponds to a 2.4‐fold increase compared to that of the baseline value. These high O~2~ levels continued for 300 s after the infusion. The rHSA‐FeP solution can be utilized not only as a red blood cell substitute but also as an O~2~‐carrying medicine for the effective reoxygenation of the hypoxia solid tumor. © 2002 Wiley Periodicals Inc. J Biomed Mater Res 64A: 48–51, 2003