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Oxygenated chalcones and bischalcones as a new class of inhibitors of DNA topoisomerase II of malarial parasites

✍ Scribed by Shalini Srivastava; Shweta Joshi; Alok R. Singh; Sarika Yadav; A. S. Saxena; V. J. Ram; Subhash Chandra; J. K. Saxena

Book ID: 105770828
Publisher: Springer-Verlag
Year: 2007
Tongue: English
Weight: 324 KB
Volume: 17
Category: Article
ISSN: 1054-2523
DOI: 10.1007/s00044-007-9057-0

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Malaria, a life-threatening disease caused by parasites of the genus Plasmodium, affects 500 million people annually, of which more than one million die. [1] The emergence of multi-drugresistant strains of Plasmodium falciparum, the parasite that causes the deadliest form of malaria, exacerbates the