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Oxygen supply to immobilized cells

โœ Scribed by Patrick Adlercreutz; Bo Mattiasson

Publisher
Springer
Year
1982
Tongue
English
Weight
640 KB
Volume
16
Category
Article
ISSN
1432-0614

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โœฆ Synopsis

Oxygen supply is a critical point in technical processes when aerobic cells are used in immobilized preparations. This report concerns the use of hemoglobin or emulsions of perfluorochemicals (completely fluorinated organic compounds) to carry oxygen to immobilized cells. Both methods work well and do not seem to harm the cells. The perfluorochemical method of improving oxygen supply showed a higher operational stability than the hemoglobin method.

๐Ÿ“œ SIMILAR VOLUMES

Oxygen supply to immobilized cells
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Packed-bed bioreactors (PBR) have proven to be efficient systems to culture mammalian cells at very high cell density in perfusion mode, thus leading to very high volumetric productivity. However, the immobilized cells must be continuously supplied with all nutrients in sufficient quantities to rema