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Oxygen sensing requires mitochondrial ROS but not oxidative phosphorylation

✍ Scribed by Joslyn K. Brunelle; Eric L. Bell; Nancy M. Quesada; Kristel Vercauteren; Valeria Tiranti; Massimo Zeviani; Richard C. Scarpulla; Navdeep S. Chandel


Book ID
116372337
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
324 KB
Volume
1
Category
Article
ISSN
1550-4131

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The contribution of mitochondrial free radical production towards the initiation of lipid peroxidation (LPO) and functional injury in the post-ischemic heart is unclear. Using the isolated rat heart model, the effects of the uncoupler of mitochondrial oxidative phosphorylation dinitrophenol (DNP, 50