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Oxygen concentration regulates EGF-induced proliferation and EGF-receptor down regulation

โœ Scribed by Deborah A. Wing; Glenda D. Talley; Thomas G. Storch


Book ID
117058734
Publisher
Elsevier Science
Year
1988
Tongue
English
Weight
350 KB
Volume
153
Category
Article
ISSN
0006-291X

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The epidermal growth factor receptor (EGF-R), after activation by its ligands, stimulates a cascade of intracellular events leading to cellular proliferation. Its expression is increased in various forms of cancer as a consequence of altered regulation. Our objective was to study potential negative