This paper describes the influence of iron on both nuclear and cytosolic melatonin contents in several tissues of chicks. The neurohormone melatonin was estimated by means of radioimmunoassay. Iron, administered as FeCI3, decreased the nuclear melatonin level in a variety of tissues, including brain
Oxyferriscorbone elevates the total iron content of blood but not brain
β Scribed by D. T. Dexter; Dr. P. Jenner; Dr. C. D. Marsden
- Publisher
- John Wiley and Sons
- Year
- 1989
- Tongue
- English
- Weight
- 421 KB
- Volume
- 4
- Category
- Article
- ISSN
- 0885-3185
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β¦ Synopsis
Following the intravenous infusion of oxyfemscorbone into the tail vein of the rat, the blood and brain metal ion content was measured over the following 72 h period. Administration of oxyfemscorbone increased the total iron content of blood for up to 24 h following intravenous infusion. In contrast, there was no increase in the total iron content of the cerebellum or striatum. Overall, there was no change in total zinc or copper content of the blood or brain following oxyfemscorbone administration. The effect of oxyfemscorbone in Parkinson's disease may not be related to any alteration in total iron content of the brain.
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