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Oxyferriscorbone elevates the total iron content of blood but not brain

✍ Scribed by D. T. Dexter; Dr. P. Jenner; Dr. C. D. Marsden


Publisher
John Wiley and Sons
Year
1989
Tongue
English
Weight
421 KB
Volume
4
Category
Article
ISSN
0885-3185

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✦ Synopsis


Following the intravenous infusion of oxyfemscorbone into the tail vein of the rat, the blood and brain metal ion content was measured over the following 72 h period. Administration of oxyfemscorbone increased the total iron content of blood for up to 24 h following intravenous infusion. In contrast, there was no increase in the total iron content of the cerebellum or striatum. Overall, there was no change in total zinc or copper content of the blood or brain following oxyfemscorbone administration. The effect of oxyfemscorbone in Parkinson's disease may not be related to any alteration in total iron content of the brain.


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