Selenocysteine-Mediated Native Chemical
โ
Richard Quaderer; Axel Sewing; Donald Hilvert
๐
Article
๐
2001
๐
John Wiley and Sons
๐
German
โ 108 KB
C-Terminal peptide thioesters are shown to react efficiently with peptide fragments containing an Nterminal selenocysteine to give selenoproteins. In analogy to the native chemical ligation of thioesters and peptides containing N-terminal cysteines, the selenol presumably attacks the thioester nucle