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Oximes, amidoximes and hydroxamic acids as nitric oxide donors

✍ Scribed by Leonid N. Koikov; Natalia V. Alexeeva; Elena A. Lisitza; Emmanuil S. Krichevsky; Nikita B. Grigoryev; Alexandr V. Danilov; Irina S. Severina; Natalia V. Pyatakova; Vladimir G. Granik

Book ID: 111730075
Publisher: Royal Society of Chemistry
Year: 1998
Tongue: English
Weight: 82 KB
Volume: 8
Category: Article
ISSN: 0959-9436
DOI: 10.1070/mc1998v008n04abeh000891

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## Abstract Five licofelone ([2,2‐dimethyl‐6‐(4‐chlorophenyl)‐7‐phenyl‐2,3‐dihydro‐1__H__‐pyrrolizin‐5‐yl]acetic acid) nitric oxide donor conjugates were developed by a parallel synthesis approach. The biological screening revealed that compounds with a propyl (**6b**), butyl (**6c**), or octyl (**