Oxime and Oxime Ether Derivatives of 1,4-Benzothiazine Related to Oxiconazole

✍ Scribed by Lara Milanese; Nicola Giacchè; Fausto Schiaffella; Anna Vecchiarelli; Antonio Macchiarulo; Renata Fringuelli

• Publisher: John Wiley and Sons
• Year: 2007
• Tongue: English
• Weight: 222 KB
• Volume: 2
• Category: Article
• ISSN: 1860-7179
• DOI: 10.1002/cmdc.200700066

✦ Synopsis

Abstract

The synthesis, in vitro antifungal activity, and molecular docking experiments of some oxime and oxime ether derivatives of azole 1,4‐benzothiazine are reported herein, with the aim of evaluating the influence of a partially constrained scaffold that is structurally related to Oxiconazole and bearing the 1,4‐benzothiazine moiety, on the inhibition of Candida albicans CYP51.